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Not long ago, Dr. Jasdave Chahal had a great idea and a big problem. The Massachusetts Institute of Technology virologist was driven by a dream to use messenger RNA to train bodies to defend themselves against disease. With some considerable effort, Chahal managed to program RNA to create disease-specific proteins called antigens that would induce an immune response, produce antibodies, and prep the immune system for future disease.
But these RNA were big — too big. He couldn’t efficiently transmit them to cells.
Enter Chahal’s good friend and MIT associate, Dr. Omar Khan, a chemical engineer who had a solution to Chahal’s problem – customize nanomaterials that were big enough to carry the messenger RNA and compact enough to inject directly into muscle tissue, just like traditional vaccines.
Perhaps the most promising aspect is how quickly the RNA and nanomaterials can be manufactured. In just a matter of days, a large quantity of nanomaterials can be stockpiled and disease-specific RNA vaccines can be developed, according to a paper the researchers published this week in the journal Proceedings of the National Academy of Sciences.
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